Abstract Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly.There are currently no approved RSV-specific therapeutic small molecules available.Using high-throughput antiviral screening, we identified an oral drug, the prenylation inhibitor lonafarnib, which showed potent inhibition
Abstract A three-dimensional conjugate tooth surface design method for Harmonic Drive with a double-circular-arc tooth profile is proposed.The radial deformation function of the flexspline (FS), obtained through Finite Element (FE) analysis, is incorporated into the kinematics model.By analyzing the FS tooth enveloping process, the optimization of
Emotions not only take us deeper in but also reveal larger political and Notebook RAM Memory historical structures that dominate how the Grades 4 to 6 newcomers with emerging print literacy in this study shape their literacy practices.Following a humanizing approach, I conducted three qualitative, critical case studies in Ontario urban schools.Data
BackgroundThere are more than 6000 rare diseases in existence today, with the number of patients with these conditions rapidly increasing.Most research to date has focused on the diagnosis, treatment, and development of orphan drugs, while few studies have examined the topics and GIFT CARD emotions expressed by patients living with rare diseases on
Adult progeria Werner syndrome (WS), a rare autosomal recessive disorder, is characterized by accelerated aging symptoms after puberty.The causative gene, WRN, is a member of the RecQ DNA helicase family and is predominantly involved in Brakes DNA replication, repair, and telomere maintenance.Here, we report the generation of iPS cells from a patie